Fiber Laser-Assisted Synthesis of MoS2 Nanomaterials for Enhanced Anticancer and Antibacterial Activity
2025
Layal A. Jasim | Fatema H. Rajab | Ahmad W. Alshaer
Molybdenum disulfide (MoS2) is a promising nanomaterial with a wide range of applications. Its outstanding properties, good biocompatibility, and band gap characteristics allowed it to be used in biosensing, electronics, optoelectronics, and biological and medical applications. Furthermore, Biopolymers, including chitosan and PEG, are regarded as the most promising materials in the medical domain. Therefore, in this work, MoS2, MoS2-CS, and MoS2-PEG nanocomposite materials are generated using a laser ablation process. A comprehensive examination of the manufactured composites was performed using X-ray diffraction analysis (XRD), transmission electron microscopy (TEM), ultraviolet-visible spectroscopy (UV–Vis), energy Dispersive X-ray (EDX), Raman spectroscopy, and Fourier transform infrared spectroscopy (FTIR) to validate the quality and content of the newly prepared composites. Based on the results, MoS2 NPs show a minimum average size of 20 nm generated using 127.3, 250mm/s, 3 minutes irradiation. Furthermore, the recorded average size of MoS2-CS and MoS2-PEG nanocomposite were 10.5 nm and 7.8 nm, respectively. The MoS2-CS hybrid nanocomposite showed the highest antibacterial activity against E. coli bacteria, while MoS2-CS and MoS2-PEG showed the highest antibacterial activity against S.aureus bacteria compared to pure MoS2 NPs. The anticancer analysis demonstrated that the MoS2-CS nanocomposite presented the highest cytotoxic effect against the A549 cell compared to MoS2 and MoS2-PEG.
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