A Pediatric Concussion Model in Mice: Closed Head Injury with Long-Term Disorders (CHILD)
2025
Dubois, Christophe | Yan, J. | Obenaus, André | Badaut, Jérôme | Centre d'Études Biologiques de Chizé - UMR 7372 (CEBC) ; La Rochelle Université (ULR)-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) | Centre de résonance magnétique des systèmes biologiques (CRMSB) ; Université de Bordeaux (UB)-Centre National de la Recherche Scientifique (CNRS) | University of California (UC) | Loma Linda University
International audience
Mostrar más [+] Menos [-]Inglés. Pediatric concussions can result in long-term sequelae with physiological and psychological perturbations. This pediatric concussion mouse model results in long-term neuroinflammation, white matter alterations, and neuronal modifications with behavioral dysfunction. The model can be adapted to differential impact locations or repeated concussions to assess lifetime changes.
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