The poultry industry suffers from various diseases or stresses. In poultry, apart from being antipyretic, acetylsalicylic acid (ASA) is widely used to cope with different issues including heat stress, and respiratory and digestive orders. This study evaluated the beneficial and toxic effects of ASA at different dose levels in broiler birds. To evaluate these toxic and beneficial effects it is necessary to examine the physical and serum biochemical parameters as well as the histopathological changes with tissue sections taken from broiler birds under experimental trial. This study was conducted on 60 one-day-old broiler chicks purchased from a local market in Faisalabad. Chicks were reared for the first 14 days under similar conditions. On the 15th day, birds were randomly divided into 4 groups (1-4) with 15 birds in each group. Group 4 was kept as control, while groups 1, 2, and 3 were treated with ASA at the dose of 300, 600, and 1200 mg/L of drinking water for 21 days. There were 3 samplings performed at 21, 28, and 35 days post-treatment. The live body weight and carcass weight were noted on each sampling. All the visceral organs were recorded for gross pathological changes. The serum samples were collected for biochemical evaluation. Histopathology of all the visceral organs was performed to observe the microscopic changes. A significant (P<0.05) increase in live body weight at a 300mg/L dose was noted after the first 2 samplings. A significant (P<0.05) increase in the relative organ weight was recorded at 1200 mg/L. The groups treated with ASA 600 and 1200 mg/L showed increased (P<0.05) AST, ALT, and creatinine levels from that of the control group. The group treated with 1200 mg/L of ASA showed increased (P<0.05) urea, serum total protein, and albumin level in all the samplings. Histopathological changes revealed swollen hepatocytes, increased sinusoidal spaces in the liver, congestion and abnormal glomerular spaces in the kidney, congestion and alveolar disruption in the lungs, and generation of villi and cellular degeneration in the intestine in a high-dose group. The study concluded that ASA at a low dose can be used for a long time in broilers and has a growth promontory role, while high-level doses cause hepatorenal toxicity.

In breast cancer treatment, chemotherapy resistance is a major problem where many receptive tumors rebound and develop resistance. When provided in combination, cancer drugs are most successful, thus reducing the risk of developing resistant cancer cells. However, the evaluation of combination therapies has increased rapidly in recent years. Consequently, by repurposing old treatments, the discovery of additional medicines that may interact synergistically with chemotherapy is considered a current medical aim through discovering a new cancer medication or therapeutic strategy. The purpose of this research is to increase the anti-cancer activity of carboplatin (CP) by increasing the apoptotic effect of breast cancer cells (MCF-7) during in vitro experiments in combination with oxytetracycline. Our results showed a high synergistic effect between oxytetracycline and carboplatin, MCF-7 representative cell treated with carboplatin with/without different concentrations of oxytetracycline (5% and 10% of IC50). Oxytetracycline, which potentiated the action of carboplatin and/or had notable activity was reported as a single agent. This research demonstrated the synergistic relationship between oxytetracycline and carboplatin in viability assays. Surprisingly, our findings suggest that inhibiting treatment strategies can extend carboplatin’s therapeutic window, potentially allowing for cancer therapy.

Considering the lack of information about livestock diseases on Brazilian oceanic islands, the occurrence of bovine brucellosis was investigated on the island of Fernando de Noronha, state of Pernambuco, Brazil. Serum samples were collected in October 2009, from all the 105 cows raised on the island at that time. These were examined concurrently using the Rose Bengal test and the Complement Fixation Test. All the samples were negative in both tests, indicating that the cows on the island were likely free from infection by smooth forms of Brucella. These results can partly be explained by the prohibition of introduction and importation of both small and large-sized animals that had been implemented through District Decree 19 of February 28, 2004.

The COVID-19 cases in Tanjung Jabung Barat Regency, Jambi, have has risen significantly daily. This significant increase in cases illustrates that the people are less than optimal in complying with the health protocols established by the government. This phenomenon concluded that public compliance in efforts to prevent COVID-19 has a vital role in preventing the spread. This study aims to describe the level of compliance towards prevention efforts of COVID-19 in the community. We use a descriptive survey method with probability sampling techniques to obtain the data. The subjects in this study were the community of Tanjung Jabung Barat, Jambi Regency, who were17 years old with a sample size of 400 samples. Collecting data using a questionnaire in a validated form and distributed to the public via social media. The data analysis in this study is the frequency distribution analysis (univariate analysis). The results of this study shown were that 172 respondents (43.0%) had a good level of compliance, 146 respondents (36.5%) had a sufficient level of adherence, and as many as 82 respondents (20.5%) had a good level of compliance to prevent COVID-19 spreads.

This study aims to determine beef types Dark, Firm, and Dry (DFD) and Pale, Soft, and Exudative (PSE) that are sold at the Peunayong Market, Banda Aceh. A total of nine samples of beef from different sellers will be used as extracts and the pH is measured three times every 1 hour for 12 hours to determine the trend of decreasing pH. Organoleptic observations were carried out to determine the visual differences shown by the meat samples. Parameters observed were meat color, meat aroma, meat texture and surface state of the meat. The data obtained from pH measurements and organoleptic tests were analyzed descriptively. Based on the results of pH measurements seen from the decreasing trend of pH in nine samples of beef, seven of them were PSE type beef with a pH value of 5.2 and the other two samples were of good quality meat with a pH value ranging from 5.6 to 5.4. From the results of organoleptic tests for color parameters, four samples were pale, one sample was very pale and the rest were red. All the meat samples tasted normal. Meat texture and surface condition for soft-textured meat has a wet surface, while hard-textured meat has a dry surface.

Nutmeg (Myristica fragrans Hout) is a leading commodity from Aceh Province. The high yield of nutmeg oil and its distinctive aroma makes it in demand by the world market. The production of nutmeg plants is currently decreasing due to the disturbance of nuisance organisms so that nutmeg plants get sick and die. Appropriate agro eco-management of the nutmeg system is thought to overcome these problems. Such as by conserving the diversity of arthropod communities. Information regarding the presence of arthropods in nutmeg cultivation is very limited in South Aceh District. This study investigates the abundance of arthropods in nutmeg cultivation in different vegetation to detect the causes of the decline in nutmeg production in the South Aceh district. Sampling was carried out at 2 locations with different vegetation conditions, using the determining sub-samples. Each location consisted of 200 individual nutmeg plants, and at each location, several 20 individual nutmeg plants were assigned as samples. The results showed that the total collection of arthropod populations at the location I found nine orders, namely Araneae, Coleoptera, Dermaptera, Diptera, Homoptera, Hemiptera, Hymenoptera, Isoptera, and Orthoptera. Location II found 12 orders, namely Araneae, Blattodea, Coleoptera, Dermaptera, Diptera, Embioptera, Homoptera, Hemiptera, Hymenoptera, Isoptera, Orthoptera, and Phasmatodea). The class of insects and arachnids found at these two locations is part of the Phylum Arthropoda.

The research was at determining the knowledge, attitudes, and actions of farmers on the Qanun number 3 of 2016 regarding the control of productive cows and buffaloes to avoid slaughtering productive cows and buffaloes so that livestock populations are maintained. This research was conducted using a survey method for three months starting from May 2021 to July 2021. Breeders were selected using the purposive sampling method and interviews were conducted by filling out a validated questionnaire. The data analysis method used was descriptive qualitative analysis using a structured questionnaire to 110 farmer respondents with the criteria of having 2 years of experience in raising cattle, and raising female cows. The livestock population has increased since Qanun Number 3 was issued in 2016. The results of this study indicate that the level of knowledge of farmers is in a good category (72.5%), attitude is a very good category (83.2%) and action is good category (72.5%).

This study aims to determine the presence of Salmonella sp. and Staphylococcus aureus bacteria in rendang meat, fried chicken, fried fish, and omelets, as well as in the hands of food handlers in the Food Management Place (TPM). Ulee Lheue Sea Port by using laboratory tests. The study used five samples of food and five samples of food handlers' hands taken from the Food Management Place (TPM) of Ulee Lheue Seaport. Bacterial analysis on food samples in the laboratory using the Total Plate Count (TPC) method. Meanwhile, the Replicate Organism Direct Agar Contact (RODAC) method was used to examine food handlers' hands. Laboratory tests resulted from five food samples and five food handlers' hand samples that Salmonella sp. was found in omelets, and Staphylococcus aureus was found in beef rendang, fried chicken, fried fish, omelets, and hand samples of food handlers. It is necessary to conduct hygiene and environmental sanitation counseling at TPM around Port of Ulee Lheue.

The leaves of Bandotan (Ageratum conyzoides) are a plant thought to have antibacterial properties. This study aims to determine the sensitivity of Bandotan leaf extract in inhibiting the growth of the bacteria Pseudomonas aeruginosa. This study used a stock extract of Bandotan leaves from the Pharmacology Laboratory and a bacterial isolate of P. aeruginosa in the Microbiology Laboratory of the Faculty of Veterinary Medicine, Universitas Syiah Kuala, which was identified by Gram staining, indole test, Methyl Red test, and confectionery test. The research method was carried out by planting the re-identified bacterial isolates on Nutrient Broth (NB) media, incubated at 37ºC for 24 hours. Then the turbidity composition of the isolates was arranged to match the turbidity in 0.5 McFarland solution. Furthermore, the sensitivity test of the extract on Mueller Hinton Agar (MHA) media was carried out by levelling the bacterial isolates on the surface of the media and attaching a disc containing bandotan leaf extract with a concentration of 25%, 50%, 75% and gentamicin disk as a positive control and distilled water as a negative control. All treatments were incubated at 37ºC for 24 hours, and then the inhibition zone was measured using millimeters (mm) callipers. The results showed that concentrations of 25%, 50% and 75%, respectively, had an inhibition zone of 8.16 mm, 9.82 mm, and 16.08 mm, respectively. In contrast, the average inhibition zone for gentamicin was 25, 30 mm and 0 mm distilled water. Therefore, it can be concluded that the Bandotan leaf extract is sensitive to growth inhibition of P. aeruginosa bacteria.