Peganum harmala L. (Zygophyllaceae) known locally as harmel is a medicinal plant. In traditional medicine, its seeds have long been used for therapeutic purposes because of their richness in β-carboline alkaloids. This study aimed to evaluate the maternal and developmental toxicity during pregnancy by daily IP administration of 7.99 mg/kg/day (1/20 DL50) of total alkaloids extract in P.harmala’ seeds. The results summarized in confirmed pregnancy rates were high 90-100%, decreased locomotor activity, paralysis, and hypothermia. Maternal body weight and weight gain changes were statistically significant in all pregnant. Precisely, the relative weight of ovaries was significantly changed in all the groups treated. The ALAT and gamma GT concentrations show a significant change in the group treated for seven days. Significant changes in the total and indirect bilirubin levels were observed in all treated groups. The hormonal analysis showed a significant decrease in FSH levels in a treated group for seven days and two weeks, Progesterone levels were increased significantly in treated groups for seven and three weeks and increased significantly in a treated group for two groups, however, the levels of Estrogen were changed significantly only in the treated group for three. The results show a significant difference in total resorbed litters and the number of fetus deaths in the group treated for three weeks. The fetus weight in the group treated for two weeks was significant. The results show a significant decrease in the number of implantations and an increase in pre-and post-implantation loss rates, and there were no developed live or dead, and no resorbed fetuses in all treated dams, there were only implantation sites in both uterine horns. The total extract of the alkaloids in the seeds of P. harmala has adverse effects on maternotoxicity, embryonic development, and abortion.

Yürütülen çalışmada sürdürülebilir kaynaklardan çevre dostu biyopolimerlerin elde edilmesi ve biyomalzeme olarak kullanılabilirliği araştırılmıştır. Bu amaçla, sığır aşil tendonundan kollajen, ipek böceği kozasından fibroin, kahverengi deniz alglerinden sodyum alginat ve aloe vera jelinden biyoaktif bileşenler izole edilerek saflaştırılmıştır. Ürün verimi kollajen, fibroin, sodium alginat ve aloe vera için sırasıyla %79.8 (w/w), %69.49 (w/w kozadan), %35.1 (w/w) ve %1 (w/v jeldeki kuru miktar) oranında hesaplanmıştır. Bu biyomoleküllerden dondurarak kurutma yöntemi ile doku iskeleleri hazırlanmıştır. Ancak, aloe vera jeli katı formada yapı bütünlüğünü koruyamayarak 3-boyutlu iskele yapı oluşturamamıştır. Fibroin, kollajen ve sodyum alginat iskelelerin FTIR analizleri ürünlerin saf olarak elde edildiğini, liyoflizasyon sırasında kimyasal yapının korunduğunu göstermiştir. SEM ile yüzey analizleri ise iskelelerin doku mühendisliği uygulamaları için uygun olduğunu desteklemiştir. Sonuç olarak, petrol kaynaklı polimer yerine sürdürülebilir kaynaklardan, genel olarak oda şartlarında bioaktif polimerler yüksek verimle elde edilmiş ve biyomalzeme olarak kullanılabilecekleri belirlenmiştir. Biyomoleküllerin bu şekilde sürdürülebilir kaynaklardan elde edilmesi hem hammadde sorununun hem de polimer kaynaklı çevresel kirliliğin çözümünde önemli potansiyele sahiptir.

In this study, it was aimed to optimize the ultrasonic rehydration conditions of dried tomatoes.Rehydration conditions were optimized by Response Surface Method (RSM). The optimization of ultrasonic (37 kHz) rehydration conditions were performed with independent variables at different temperatures (20-80°C), time (2-60 min) and water ratios (1/50-1/100 g/g water), and rehydration ability, color a* (redness) and texture values were selected as responses (dependent variable). The estimated and experimental analysis results were compared in the selection of the optimum rehydration condition. As a result, it was determined that ultrasonic rehydration at 58°C/54 min/72 ml water conditions could be used as the optimum point. At the selected optimum point, the rehydration ability, color a* value and texture values were determined as 2.82±0.16, 13.09 ±1.63 and 0.46±0.13 N, respectively. These results are seen as proof that ultrasound application can be used in the rehydration of dried tomatoes.

Pestil is one of the important foods traditionally produced in Türkiye, with high energy, vitamin and mineral content. It is obtained by naturally drying the pulp obtained from different kinds of fruits after mixing it with ingredients such as sugar and flour. In regions where the fruiting period depends on the season, fruit pulp is produced in order to benefit from it in winter. In addition, bioactive components originating from the fruit increase the nutritional value. In this study, the physicochemical and antioxidative properties of the pestil obtained from three different Hawthorn fruits (Crataegus meyeri, Crataegus turkestenica and Crataegus orientalis) known to have positive effects on health were investigated. The results revealed that, depending on the fruit type, pestil samples have high antioxidative properties (IC50: 50.11±0.16-52.1±2.14 mg/mL) due to the high phenol content (39.8±0.16-52.95±1.21 mg GA/g DW). In this context, in the present study, it has been seen that the pestil prepared with the traditional method from three different Hawthorn fruits should be industrially produced as a product for people to access healthy and various foods today.

The common name for Viburnum opulus in Türkiye is "gilaburu". Despite its bitter and acrid taste, it is consumed as fruit juice or products such as jam, marmalade, jelly. They have antioxidant properties as they contain high levels of phytocompounds such as anthocyanin, phenolics, triterpenoids and vitamins. In the study, the fruits of V. opulus grown in Sivas, Kayseri and Yozgat villages were found to contain palmitic acid (C 16:0), oleic acid (C 18:1), linoleic acid (C 18:2), myristic acid (C 14:0), palmitoleic acid (C 16:1), stearic acid (C 18:0), heptadesanoic acid (C17:1), eicosenoic acid (C 20:1), eicosadienoic acid (C 20:2), lauric acid (C 12: 0), margaric acid (C 17:0), pentadecanoic acid (C 15:0), caprylic acid (C 8:0) and gincoloic acid (C 15:1) were examined. In the study, it was observed that the dominant fatty acids were palmitic acid (C 16:0), oleic acid (C 18:1) and linoleic acid (C 18:2). Similarly, in the examples, lauric acid (C 12:0), margaric acid (C 17:0), pentadecanoic acid (C 15:0), caprylic acid (C 8:0) and gincoloic acid (C 15:1) found in trace amounts.

In this study, the production technology level of enterprises, meat and meat products, slaughterhouses, and combines; operating in the red meat industry in the TR83 Region and the practical criteria for selecting these technology levels have been determined. Within the scope of the study, the data obtained by face-to-face interviews with the managers of meat and meat products processing enterprises, slaughterhouses, and combines operating in the provinces of Amasya, Çorum, Samsun, and Tokat in the TR83 Region were evaluated. Analytical Hierarchical Process (AHP) and TOPSIS methods were used to determine the production technology level. In the study, the level of production technology (alternatives) was considered as modern production technology and traditional production technology while the criteria are determined as family business, modern conditions, production capacity, market width, modernization, modern facility, hygiene, and quality. As a result of the study, modern production technology was determined as very important by 85% points with the AHP method and 99% points with the TOPSIS method. It has been concluded that the most essential criteria in determining the level of production technology are quality (0.291), hygiene (0.273), and modern conditions (0.106). The technology level used in production is important in terms of providing sufficient red meat supply and healthy and reliable food production and consumption. Therefore, it has been concluded that encouraging modernization in is this field and allowing enterprises to use modern technology will support production.

The present study, it was aimed to determine the effect of antioxidants added to culture media on blastocyst development rates in in vitro embryo production. The material of the study consisted of oocytes collected from the ovaries taken from the slaughterhouse. Cumulus oocyte complexes (COC) were collected and classified under a stereomicroscope. Oocytes included in the study were subjected to maturation and fertilization stages. Probable zygotes were transferred to the culture (IVC) containing antioxidants (L-ergothionine 100 μM (n: 163), Vitamin E 100 μM (n: 151) Cysteamine 50 μM (n: 154) and were cultured in a tri gas incubator (Hera Cell- 6% O2%, 6%CO2, 88%N). Blastocyst rates and embryo quality were determined on the 6th and 7th days in culture medium. Differences in IVMFC stages were evaluated by chi-square test. 966 oocytes were collected from 162 ovaries collected from the slaughterhouse. It was determined that the number of oocytes per ovary was 5,96, and the number of A and B quality oocytes was 4.26. It was determined that 655 (94.93%) of a total of 690 oocytes undergoing in vitro maturation were mature. The cleavage rates of the groups were 83.44%; 80.79%; 79.87%, and 83.96%, respectively. 140 (21.37%) blastocysts were obtained from 655 oocytes taken into the culture stage and the blastocyst rates in the groups were 33.13%; 8.61%; 7.79%, and 32.62%, respectively. As a result of the study, it was determined that the rates of blastocysts in the L-ergothioneine added the group was similar to the control group, but the blastocyst rates decreased significantly in the cysteamine and Vitamin E added groups. It was thought that this decrease might have been affected by the dose of antioxidants or the adequacy of oocyte development

It is required to increase the amount of coagulant enzyme substitutes obtained from various sources that are equivalent to animal rennet in order to meet the rising demand for cheese. This study looked into the availability of plant-based enzymes as an alternative to rennet made from animals and microorganisms, which are frequently employed in the manufacturing of white cheese. Using animal (100% chymosin), microbial (obtained from Muchor miehei), and plant-based (Safflower seed, 80% chymosin-20 percent pepsin, purified from Cartamus tinctorius L.) enzymes, 6 varieties of raw and pasteurized milk cheese were made for this purpose. The values of SH, ripening index, water-soluble nitrogen (WSN), nitrogen dissolved in trichloroacetic acid (TCA), and yeast-mold increased after storage in cheeses made with various coagulant enzymes. During storage, the values for dry matter, pH, protein, Total Aerobic Mesophilic Bacteria (TAMB), lactobacilli, lactococci and coliforms all reduced. In terms of L*, a* and b* values, different rennet usage was discovered to be significant among cheese samples. The casein protein began to hydrolyze and the strength of the bands decreased in SDS-PAGE with the breakdown of the αs-casein and β-casein fractions on the 90th day of maturation in P1 and P4 numbered cheeses, which used plant-based enzyme made from raw and pasteurized milk. These changes in casein fractions resulted in a bitter taste in cheese made with plant-based enzymes. The use of plant-based enzymes in the manufacturing of white cheese was shown to produce results that were comparable to those of animal and microbial enzymes and did not have any negative effects on the cheese's physicochemical and microbiological quality parameters. When making fresh white cheese, the plant-based enzyme extracted from Carthamus tinctorius L. can be employed as a promising source of plant coagulants.

Goat milk has a great importance for human nutrition considering its nutrient content. In addition, the demand for goat milk and products derived from goat milk has increased in recent years. However, the microbiological properties of milk can directly affect human health. In this study, it was aimed to determine the nutrient content and some microbiological properties of goat milk obtained from different farms. In the study, hand milking farms were determined. After milking, a sufficient amount of milk sample was taken and brought to the laboratory at +4°C. In the milk samples, the composition of the milk, the total number of aerobic mesophilic bacteria, the number of yeast-mold and coliform bacteria were determined. The highest protein, lactose and solids ratio (%) was obtained in milk samples taken from farms 2 and 4. The highest fat content in milk was determined in the sample taken from farm 4. It was observed that the milks of farms 2, 3 and 4 had similar mineral substance amounts. Total aerobic mesophilic bacteria (PCA) count (191×104), yeast-mold (PDA) count (42×103) and coliform bacteria (VRBA) count (710×102) were determined in farm 2. As a result, in terms of some milk components were determined statistical differences between farms. The main difference is in terms of milk hygiene. However, it was determined that the milk showed significant changes in terms of microbiological properties according to the farms from which they were obtained. It can also be said that these changes may affect the health of people who directly or indirectly consume these milks.

Ülkemiz florası yerel buğdaylar bakımından önemli bir çeşitliliğe ev sahipliği yapmaktadır. Bu araştırmada 20 yerel ekmeklik buğday hattı ile 5 tescilli ekmeklik buğday çeşidinin verim ve bazı verim unsurları yönüyle karşılaştırılarak ümit var genotiplerin belirlenmesi amaçlanmaktadır. Bu kapsamda tarla denemeleri 2012-2013 ve 2013-2014 yetiştirme sezonlarında tesadüf blokları deneme desenine uygun olarak üç tekerrür ile Çanakkale’de kurulmuştur. Ekmeklik buğday genotipleri bitki boyu, başak uzunluğu, başaktaki başakçık sayısı, başak ağırlığı, başaktaki tane ağırlığı, başaktaki tane sayısı, metrekarede başak sayısı, metrekarede tane sayısı, biyolojik verim, hasat indeksi ve tane verimi özellikleri bakımından değerlendirilmiş, elde edilen sonuçlar varyans analizi ve duncan testi ile yorumlanmıştır. Varyans analizi sonucunda genotipler arasındaki fark istatistiksel olarak önemli bulunmuştur. Tescilli çeşitler tane verimi, hasat indeksi, başak ağırlığı, başakta tane ağırlığı, başakta tane sayısı ve metrekarede tane sayısı özellikleri bakımından yerel hatlardan üstün bulunmuştur. Buna karşılık yerel hatların yüksek bitki boyu, biyolojik verim ve başakçık sayısı bakımından öne çıkarak tane özellikleri hedef alınarak ıslah edilmiş tescilli çeşitlere kıyasla daha gelişmiş bir vejetatif aksama sahip oldukları tespit edilmiştir. Yüksek tane verimleri ile öne çıkan Hakkâri TR 47982/5 and Kırklareli TR 38316/2 hatları ise ümit var genotipler olarak belirlenmiştir.