Hospital gardens, located within urban open-green areas, are places created for patients coming to the hospital, their relatives and the staff working in the hospital to spend time in an environment where they can renew themselves. The importance of these places is increasing day by day. The purpose of this study is to examine the landscape design of the Selcuk University Faculty of Medicine hospital garden located on the Selcuk University Alaeddin Keykubad Campus. The findings show that the hospital garden was generally not designed in accordance with landscape design principles. With the suggestions developed, this hospital garden can be redesigned in accordance with landscape design principles and made more comfortable for people using the hospital garden.

Telomeres are natural nucleoprotein structures that cover the ends of chromosomes. The phenomenon of telomere shortening, which plays a crucial role in maintaining the stability of the genome, occurs gradually over time when cells undergo division due to the end replication issue. Multiple studies have demonstrated a correlation between telomere shortening and a range of illnesses, including diabetes, dyslipidemia, cardiovascular disease, cancer, and mortality. Diet and lifestyle can affect telomere length. There exists a beneficial association between telomere length and the Mediterranean diet, particularly with regards to the consumption of dietary fiber derived from whole grains and vegetables. Micronutrients such as vitamins and trace elements also play a role in cell metabolism.  Some micronutrients, such as vitamin D, folate, and vitamin B12, are associated with telomere biology and cellular aging. Vitamin B12 is essential for DNA synthesis and epigenetic methylation processes. The present systematic review examines the results from clinical trials conducted in humans evaluating the role of vitamin B12 on telomere length. Cellular senescence is a state characterized by inflammation, altered cellular metabolism, genomic instability, and telomere dysfunction, which can be induced by changes in methylation patterns and oxidative stress. Vitamin B12 maintains antioxidative defense. Through these pathways, sufficient amounts of vitamin B12 may potentially play a role in the restoration of DNA damage. Most of the evidence is based on very few randomized clinical trials. Therefore, more extensive prospective cohort studies and better-designed randomized clinical trials are required to validate the correlations outlined in this review.

Bu çalışma, Türkiye’nin Göller Bölgesi’nde farklı lokasyonlarda yabani olarak yetişen Prangos platychlaena (endemik) bitkisinin meyvelerinin uçucu yağ oranını ve bileşenlerini belirlemek amacıyla yürütülmüştür. Türe ait meyve örnekleri iki farklı lokasyondan (Isparta, Sütçüler/Çandır ve Burdur, Bucak/Kızılkaya) sarı olum döneminde toplanmış, meyvelerin uçucu yağları hidrodistilasyon cihazı ile elde edilirken, uçucu yağ bileşenleri ise GC-MS cihazı kullanılarak belirlenmiştir. Çandır lokasyonunda yetişen bitkilerde meyve uçucu yağ oranı%0,16±0,02, Kızılkaya lokasyonunda ise%0,25±0,06 olarak belirlenmiştir. Çandır lokasyonundan alınan meyvelerin 54 bileşenden, Kızılkaya lokasyonundan alınan meyvelerin ise 44 bileşenden oluştuğu belirlenmiş, türün meyvelerinde toplam 73 farklı bileşen tespit edilmiştir. Uçucu yağı oluşturan bileşenler ve oranları lokasyonlara göre kalitatif ve kantitatif varyasyonlar göstermiştir. Her iki lokasyonda da uçucu yağı oluşturan ana bileşenler germacrene-D (%17,08-%20,24), β-bisabolene (%7,53-%17,83), β-copaene (%0,92-%11,70), caryophyllene oxide (%6,23-%6,30), β-farnesene (%3,21-%5,66), δ-cadinene (%3,50-%3,87) ve ledane (%3,35-%3,22) olarak tespit edilmiştir. Çalışmada türün yetiştiği bölgenin ekolojik faktörlerinin, özellikle rakımın uçucu yağ oranı ve bileşenleri üzerinde önemli bir etkiye sahip olduğu anlaşılmıştır.

Bu çalışma Çukurova Bölgesinde yetiştirilen mandaların süt yağ asit bileşimini ortaya koymak ve fonksiyonel bir gıda olarak önemini vurgulamak amacıyla yapılmıştır. Çalışmamızın materyalini oluşturan mandaların süt yağında en yüksek oranlara sahip yağ asitleri C14:0 (miristik asit) yaz mevsiminde %11,22 ve kış mevsiminde %11,34, C16:0 (palmitik asit) yaz mevsiminde %36,07 ve kış mevsiminde %35,77, C18:0 (stearik asit) yaz mevsiminde %11,23 ve kış mevsiminde %11,20 ve C18:1n9c (oleik asit) yaz mevsiminde %24,63 ve kış mevsiminde %24,77 olarak tespit edilmiştir. Yapılan analiz sonucunda mevsimin etkisi istatistiki olarak önemsiz çıkmıştır (P>0,01). Süt yağında doymuş yağ asitlerinin oranları (SFA) (%67,9 ila 68,09), tekli doymamış yağ asitlerinin (MUFA) (%28,87 ila 29,04) ve çoklu doymamış yağ asitlerinin (PUFA) (%3,04 ila 3,06) arasındadır. Çukurova Bölgesinde yetiştirilen mandalarda süt yağ asitlerinin belirlenmesi konusunda yapılan çalışma yok denecek kadar azdır. Bu noktada manda süt yağ asit kompozisyonuna ilişkin genel bir veri elde edilmesi amacı ile yapılan bu çalışma sonuçlarının mevcut durumun tespiti ve gelecekte muhtemel gelişmeler yönünde katkı sağlayacak kapsamlı araştırmalara veri oluşturabileceği öngörülmektedir.

In this study, 34 molds showing pectin degradation activity were isolated from the soil of orchards, by several tests.  By using these isolates, pectinase group enzymes; studies on pectin lyase and polygalacturonase production were performed in the batch system and under non-sterile culture conditions. 5 isolates denoting polygalacturonase activity were coded as: T1, T2, T3, T4, T5 and the best polygalacturonase activity among these isolates was determined as 354.4 U/L in T4 isolate. Thus, optimization analyses continued by the use of this isolate. Initial apricot pulp concentration, temperature, pH and incubation period were tested as optimization parameters. The effects on enzyme activities were investigated by changing the initial apricot pulp concentration in the range of 5-100 (g/L), and in this regard, polygalacturonase activity was determined as 397.4 U/L at 50 g/L. In addition, the pH parameter was analyzed in each unit between pH = 3 – 8, and the temperature was tested by increasing 5 units in the range of 5-25°C. Consequently, the maximum polygalacturonase activity was determined as 405.7 U/L at pH 5 and 406.3 U/L at 15°C. Besides, the effect of the incubation period was studied within 1-5 days and the maximum polygalacturonase activity was determined as 429.0 U/L on the 4th day (after 96 hours). As a result, the above-mentioned T4 isolate, with which the optimization studies were conducted, was identified as Sarocladium strictum (Top ekinküfü) T4 by molecular methods.

This study was carried out in Isparta University of Applied Sciences, Faculty of Agriculture, Agricultural Research, and Application Farm in 2021 to determine the effect of different irrigation water levels on tuber yield and quality parameters of the Agria potato variety. Drip irrigation method was used in the study and five different irrigation water levels (S1: 120% of the seven-day ETo, S2: 90% of the seven-day ETo, S3: 60% of the seven-day ETo, S4: 30% of the seven-day ETo, S5: No irrigation except germination and emergence) were determined based on the reference evapotranspiration (ETo). Irrigation water (IW) amounts varied between 85.66-639.26 mm and evapotranspiration varied between 296.54-825.15 mm. Different amounts of IW significantly affected the vegetative growth, yield and quality parameters of potato. As irrigation water decreased, total tuber yield and marketable yield declined. Total tuber yield and marketable yield were 46.11 t/ha and 40.59 t/ha, respectively, in S1 treatment where the maximum amount of IW was applied, while they were 12.96 t/ha and 6.37 t/ha, respectively, in S5 treatment where no irrigation was applied. Logarithmic relationships were determined between evapotranspiration and total yield and between the amount of IW and total yield. Water use efficiency was determined between 43.69-55.88 kg/(ha×mm) and irrigation water use efficiency between 32.34-51.86 kg/(ha×mm) and yield response factor (ky) was calculated as 1.19.

Son çalışmalar, astaksantinin merkezi sinir sistemi üzerinde koruyucu etkilere sahip olduğunu göstermektedir. Ancak, astaksantinin hidrojen peroksit (H2O2) ile indüklenen oksidatif hasar üzerindeki etkileri ve apoptotik ile enflamatuar sistemlerle etkileşimi hala belirsizdir. Bu nedenle, bu çalışma astaksantinin H2O2 ile indüklenen oksidatif stres sonrası glial hücre hasarı üzerindeki koruyucu etkisini ve bunda enflamatuar ve apoptotik yollarla etkileşimini araştırmayı amaçlamaktadır. Çalışmada C6 glioma hücreleri kullanıldı. H2O2 grubundaki hücreler H2O2 ile 24 saat boyunca inkübe edildi. Astaksantin grubundaki hücreler farklı konsantrasyonlarda astaksantin ile 24 saat boyunca inkübe edildi. Astaksantin + H2O2 grubundaki hücreler ise çeşitli konsantrasyonlarda astaksantin ile 1 saat boyunca inkübe edildikten sonra 24 saat boyunca H2O2’ye maruz bırakıldı. Hücre canlılığı XTT testi kullanılarak değerlendirildi. Antioksidatif etkinin gösterilmesi için total oksidatif stres (TOS) ve total antioksidatif stres (TAS) ölçümleri yapıldı. Antiinflamatuar etkinin ölçümü için ELISA yöntemi ile TNF‑α ve IL‑1β ölçümleri yapıldı. Antiapoptotik etkinin ölçümü için ELISA yöntemi ile kaspaz 3, BAX ve Bcl‑2 ölçümleri yapıldı. H2O2 grubuna kıyasla astaksantin + H2O2 grubunda, astaksantin C6 hücrelerinde hücre canlılığını önemli ölçüde artırdı. Aynı zamanda, astaksantin antioksidatif stresin bir göstergesi olan TAS seviyelerini önemli ölçüde artırırken TOS seviyelerini düşürdü. Ayrıca, astaksantin TNF-α ve IL-1β gibi enflamasyon faktörlerini önemli ölçüde azalttı. Bunun yanı sıra, astaksantin apoptotik proteinleri olan bölünmüş kaspaz-3 ve Bax seviyelerini önemli ölçüde azaltırken, anti-apoptotik Bcl-2 protein seviyelerini artırdı. Özetlemek gerekirse, astaksantin, oksidatif stres, apoptoz ve enflamasyon belirteçlerini etkili bir şekilde inhibe ederek anlamlı bir koruyucu etki sağlamaktadır. Bununla birlikte, olası temel mekanizmaları ele almak için daha kapsamlı bir araştırma gerekmektedir.

The concept of lighting is of great importance in providing the security that people need so that they can have a quality of life and in meeting their aesthetic needs. Lighting design is related to the physical structure and the environment, and thanks to the lighting design, the aesthetic and functional needs of people will be met and the quality of life will be increased. The need to reflect the historical, cultural and aesthetic values of the city has brought the issue of urban lighting to the agenda. Lighting systems, which are applied without paying attention to the necessary lighting standards and criteria, cause some problems in urban spaces. One of these problems is light pollution; It is generally defined as the use of light in the wrong place, in the wrong amount, in the wrong direction and at the wrong time. Light pollution adversely affects the natural life and daily lives of people, and it is necessary to take various measures to eliminate such negativities in human life, to detect and eliminate these problems. In this study; The standards for the lighting of the city parks obtained by the literature studies were determined, the current lighting situation of the Butterfly Valley Park and the recommended lighting design produced by the Relux software in accordance with the standards. According to the findings; In the current lighting project, the total power consumed as a result of the lighting of all the lamps of the area has been calculated as 96 005.0 W. In the proposed lighting project, the total power consumed as a result of the burning of all lamps was calculated as 27 630.0 W. The obtained energy gain was found to be 96 005.0 W – 36 700.0 W = 68 375.0 W. As a result of working in the light of this information, energy savings of 1 in 3 have been achieved.

Agricultural farming is a complicated system that involves continuous interactions among its multiple components over a period of time. The series of activities involved in farming practices have enormous contributions to ensure food security for the humanity. With the passage of time, agriculture sector faces diversified challenges like high food demand of rapidly growing population, scarcity of available resources and adverse effect of climate change. In developing countries like Bangladesh, food sufficiency is mostly achieved through intensive farming which has detrimental effects on natural resources, surrounding environment, and the whole ecosystem. The review attempts to discover the potentials of conservation agriculture practices for sustainable crop productivity and economic profitability of smallholder farmers in Bangladesh. This study revealed that conservation farm management practice is a cost-effective modernized technique that has the ability to accelerate crop productivity and farmers income through minimum utilization of agricultural inputs. Although the concept of conservation agriculture is widely practiced in other parts of the world, Bangladesh is experiencing a slow rate of adoption during the last few years. The policy implication of the study suggests that the government should take coordinated and combined initiatives involving both public and private sector organizations to incorporate this concept into the mainstream agricultural system of Bangladesh.

Chlorophyll meters manage both the amount and duration of nitrogen fertilizer application based on the principle that the chlorophyll or nitrogen content of plants should be maintained throughout their development. For smallholders in developing countries, the use of a hand-held meter to manage nitrogen fertilizer in rice and wheat is the most popular method. The adoption of nitrogen management strategies based on close sensing using chlorophyll meters and optical sensors will largely depend on the inclusion of specific economic analysis in future research. The importance of using sensors and chlorophyll meters for nitrogen fertilizer management depends on how successful current practices have been. In this study, five different nitrogen rates (0, 80, 120, 160, 200 kg N ha-1) were applied to two different wheat varieties, and the effect of these different nitrogen rates on wheat protein content was investigated in a randomized block design. A quadratic polynomial model described the relationship between protein content and nitrogen rates.