Studies on the yeast-like fungi associated with bovine mastitis, 2: sensitivity of yeast-like fungin to antifungal agents

Yeo, S.G.; Choi, W.P. . Coll. of Agriculture, Dept. of Veterinary Medicine

Studies on the yeast-like fungi associated with bovine mastitis, 2: sensitivity of yeast-like fungin to antifungal agents

1982

Yeo, S.G. | Choi, W.P. (Kyungbuk National Univ., Daegu (Korea R.). Coll. of Agriculture, Dept. of Veterinary Medicine)

This experiment was carried out to know the 133 isolates of yeast-like fungi. The antifungal agents tested were nystatin, griseofulvin, cycloheximide, 5-fluorocytosine, miconazol, clorimazole and tolnaftate. In general, clotrimazole, miconazol and 5-fluorocytosine were more effective in antifungal activity in vitro against the test organisms than the rest of the agents tested. However, some of the isolates showed higher resistance to certain antifungal agents compared to the other isolated of the same species. They were: 1C. albicans isolate to 5-fluorocytosine: 1 C. albicans to 5-fluorocytosine, miconazol and clotrimazole: 1 c. krusei to 5-fluorocytosine and cycloheximide; and 11 C. tropicalis isolates to cycloheximide. The minimum inhibitory concentrations (MIC) of clotrimazole were 12.5 mg/ml or lower for all isolates tested except one C. albicans isolate, for which MIC of the drug was 100 g/ml. On the other hand, the MIC's of cycloheximide were 6.5 mg/ml or lower for all isolates except the following: all isolates of C. albicans (100 mg/ml), 11 C. pseudotropicalis (200 mg/ml) and Rhodotorula sp. (25-50 mg/ml), 11 C. tropicalis isolates (100 mg/ml) and 1 C. Krusei isolate (200 mg/ml)

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