Studies on the antigenicity and immunogenicity of Newcastle disease virus inactivated with binary ethylenimine

Park, B.K.; Jeon, Y.S.; Lee, Y.S. . Coll. of Veteinary Medicine; Rhee, Y.O. . Veterinary Research Inst.

Studies on the antigenicity and immunogenicity of Newcastle disease virus inactivated with binary ethylenimine

1985

Park, B.K. | Jeon, Y.S. | Lee, Y.S. (Seoul National Univ., Suwon (Korea R.). Coll. of Veteinary Medicine) | Rhee, Y.O. (Rural Development Administration, Anyang (Korea R.). Veterinary Research Inst.)

Effects of binary ethylenimine (BEI) treatment on the inactivation of infectivity and hemagglutinin of Newcastle disease virus (NDV) were studied in comparison with those of formalin treatment. Immune responses of chickens vaccinated with BEI- inactivated NDV vaccines were also investigated. Complete loss of infectivity of NDV (BI) was observed at 3, 7, and 24 hrs after the treatment at 37 deg C with BEI concentrations of 0.01M, 0.005M and 0.001M, respectively

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