Electron microscopic observations of the vascular endothelial cells in the central nervous system of piglets infected with porcine enterovirus serotype 3
1988
Shin, T.K. (Chungnam National Univ., Taejon (Korea R.). Coll. of Medicine) | Lee, C.S. (Kyongbuk National Univ., Taegu (Korea R.). Coll. of Veterinary Medicine)
In the course of studying porcine enterovirus infection in piglets, the vascular endothelial cells in the CNS of colostrum-deprived piglets with polioence-phalomyelitis were investigated by electron microscope. The experimental piglets were orally infected with the porcine enterovirus serogroup 3 isolated in Korea and necropsied at 7 days postinoculation. Crystalline arrays of viral particles were found in the vascular endothelial cells of the spinal cord and cerebellum. Aggregates of immature viral particles were occasionally observed in the vascular endothelial cells in the meninges. The rough ER was deprived of ribosomes, irregularly dilated and associated with viral crystals. There were abundant cytoplasmic filaments, dilatation of perivascular space, perivascular cuffing, and the partial disruptions of endothelial cell membrane and basal lamina
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