Is Brucella melitensis Rev. 1 vaccine dangerous.
1980
Alton, G.G. (CSIRO, Parkvill-Victoria (Australia). Animal Health Research Lab.)
The Rev. 1 strain is an attenuated strain of B. melitensis used as a living vaccine to immunize sheep and goats against brucellosis. Numerous reports describe the excellent results obtained with vaccine, e.g. Alton and Elberg (1967) and Ulasevich et al (1975). Rev. 1 has been widely used in Greece with satisfactory results. Unfortunately there have been reports of vaccinators suffering from brucellosis, acquired apparently through handling the vaccine during the course of their work. The evidence however is circumstantial. There is no record of the Rev. 1 strain ever being isolated from a natural case of human brucellosis. This article looks into the important question of possible hazards associated with the use of Rev. 1 vaccine. The evidence available on the virulence, stability and transmissibility of Rev. 1 is summarised and an assessment made of the risks involved in handling the vaccine and what can be done about it.
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