Mutagenicities of carbonyl compounds derived from maillard reaction and their desmutagenicity mechanisms
1989
Kim, S.B. | Yeom, D.M. | Do, J.R. | Yoon, H.S. | Byun, H.S. | Park, Y.H. (National Fisheries Univ. of Pusan, Pusan (Korea R.). Dept. of Food Science and Technology) | Kim, I.S. (Tongyeong Fisheries Technical Coll., Chungmu (Korea R.). Dept. of Food Nutrition and Science)
The present study was attempted to investigate the mutagenicities of carbonyl compounds (methyl glyoxal, glyoxal, diacetyl, dihydroxyacetone, glycolaldehyde, glyceraldehyde and furfural) derived from Maillard reaction toward Salmonella typhimurium TA 100 (base-substitution mutant) without metabolic activation. And for further investigation of mutagenicity mechanism including desmutagenicity, active oxygen scavengers (cysteine, alpha-tocopherol, tris (hydroxymethyl) aminomethane, catalase, ascorbic acid) and reducing agents (glutathione, sodium bisulfite) were also used. Among carbonyl compounds tested, methyl glyoxal, glyoxal, dihydroxyacetone, glycolaldehyde and glyceraldehyde exhibited mutagenicities, and methyl glyoxal showed the strongest mutagenic activity. On the other hand, the mutagenicities of carbonyl compounds were significantly suppressed by cysteine, tris (hydroxymethyl) aminomethane, glutathione and sodium bisulfite. Also, these active oxygen scavengers and reducing agents alone did not show mutagenicity in the present study
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