The changes of plasma prostaglandin E2 level and natural killer cell activity in EL-4 leukemia cells bearing mice
1989
Kim, S.H. (Korea Cancer Center Hospital, Seoul (Korea R.). Laboratory of Cancer Pathology)
The change of plasma prostaglandin E2 level, natural killer cell activity and tumor cell growth were assayed after transplantation of EL-4 leukemia cells in C57BL/6 mice. Plasma prostaglandin E2 level was increased in EL-4 bearing mice, but indomethacin treated mice group showed low level. The tumor-derived prostaglandin E2 inhibited the post-target binding cytolytic process of natural killer activity. Indomethacin inhibited the growth of prostaglandin secreting EL-4 solid tumor
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