Role of dietary oils in the regeneration of experimental lipid metabolism disturbance
1989
Zsinka, A.J.N. | Foldes, V. | Gere, A. | Peredi, J. | Thuroczy-Thiermayer, T. (Central Food Research Inst., Budapest (Hungary))
To induce a fat metabolism disturbance, sexually mature male Wistar rats were fed isoenergetically for 6 weeks with a synthetic lipogenic diet containing 20 sunflower-oil or an oil mixture consisting of 33 sunflower-oil and 67 o/o oil rich in MCT C8C10. Recording the changes in certain lipid indices of the serum and liver, rats were fed for further 3 weeks with a normal synthetic diet containing 5 o/o of the same oils. The lipid indices of the serum and the liver, and the fatty acid composition of the liver were determined at the end of this period. The high lipid values of the serum and liver of rats, induced by the lipogenic diet, showed after a 3 weeks postfeeding with 5 o/o fats in a normal synthetic diet that the fat metabolism disturbance had become normalized. In the period of regeneration the high lipid level in the serum came closer to the normal level upon consumption of the fat mixture than on sunflower-oil alone. The high liver lipid values diminished after consumption of a normal synthetic diet with either fat. The total cholesterol content of the liver, however, was significantly lower when the rats were fed the fat mixture in the normal diet than with sunflower-oil. The fatty acid composition of the liver approximated the control value upon consumption of both fats. As an effect of the fat mixture the total fatty acid content came near to the control value /P/S = 0.96/, while upon consumption of sunflower-oil it was P/S = 1.7. By the end of the regeneration period the high C18:2/C20:4 quotient formed upon the consumption of the lipogenic diet diminished to a lower value /1.7/ as an effect of fat mixture, rather than upon sunflower-oil consumption /4.0/.
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