The impact of experimental zinc deficiency on growth, morbidity and ultrastructural development of intestinal tissue
1989
Roy, S.K. | Tomkins, A.M.
Animal studies were undertaken to demonstrate, the exact nature of clinical abnormalities and changes in intestinal mucosa related to diarrhoea. Four groups of weanling Sprague-Dawley rats were given zinc deficient or zinc adequate diets. Anorexia, severe growth retardation diarrhoea were observed during feeding zinc deficient diet. Intestinal mucosal weight reduced significantly in zinc deficient animal with reduction of mucosal cell population and cell size. Forty eight hours of zinc supplementation reversed the mucosal abnormalities. The study hypothesizes that zinc supplementation may improve mucosal structure and function related to diarrhoea.
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