Glucagon-related peptides in brain and gut
1993
Vaillant, C. (University of Liverpool, Liverpool (United Kingdom). Department of Veterinary Preclinical Studies) | Lund, P.K. (UNC Chapel Hill, Chapel Hill (USA). Department of Physiology) | Batt, R.M. (Royal Veterinary College, London (United Kingdom). Department of Small Animal Medicine) | Salazar, I. (Facultad de Veterina de Lugo, Lugo (Spain))
The present paper describes studies on the gut of dog and cat, and gut and brain of rat, in which the distribution of pancreatic proglucagon was examined morphologically using antisera directed towards three different epitopes of the precursor peptide, that is glucagon, NH2-glicentin and GLP-I. The three epitopes were colocalized in endocrine cells in the stomach and intestine, indicating that a proglucagon molecule similar to that in pancreas is expressed in gut endocrine cells. In rat hypothalamus, however, nerve cell bodies were stained by antiserum to glucagon, but not by antisera to NH2-glicentin or GLP-I, indicating that the glucagon-like immuno reactants in hypothalamus are not derived from a pancreatic proglucagon-like precursor
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