Insecticidally active triterpene from Artocarpus altilis Park.
1995
Williams, L.A.D. | Mansigh, A. (University of the, Mona, Kingston 7 (Jamaica). Dept. of Zoology)
Insecticidal activity directed isolation studies using adult Cylas formicarius (Summer) as the test organism, revealed that one of the active compounds present in the non-polar extract of Artocarpus altilis Park. leaves was a pentacyclic triterpene with unsaturation at the 12-13 position. The toxicity of the crude extract was reduced with each fractionation step. Thus, the order of the 48 hr LC50 (mg/g body wt.) doses for the crude ethanol extract and its hexane, methanol and ethyl acetate fractions and compounds was: 3.9 (crude extract) 5.5 (hexane fraction) 7.8 (methanol fraction) 11.5 (triterpene). The ethyl acetate fraction was inactive i.e. 10.0 mg/g dose inflicted only 20.0 percent mortality. The LC50 value derived for the triterpene when administered in 1.0 percent (v/v) dimethyl sulfoxide in acetone was 1.9 mg/g. This represent a 6 fold increase in the toxicity of the triterpene
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