Blood plasma and tissue status in fat-tailed sheep following oral or intramuscular administration of vitamin E
1996
Asadian, A.E. | Mezes, M. (Godolloi Agrartudomanyi Egyetem, Takarmanyozastani Tanszek, Godollo (Hungary))
Eighteen fat-tailed rams weighing 45-55 kg were assigned to a control and two treatment groups. One group (n=9) received vitamin E orally (100 IU/kg body weight) and the other group (n=5) received 4.500 IU/head vitamin E (dissolved in sesame oil) through intramuscular administration. Chemically, both of the vitamins were composed of dl-alpha-tocopherol acetate. Blood samples were taken from four sheep belonging to the orally-administrated group on the 3rd day and then they were slaughtered for tissue sampling. Sheep from the control and both treated groups (oral and i.m. treatment) were slaughtered on the 14th day, after blood sampling. Plasma and tissue samples from tail and subcutaneous fat, as well as from the liver and heart were examined for alpha-tocopherol and retinol using HPLC. Oral administration on the 3rd day increased alpha-tocopherol concentrations in blood plasma (P0.001), the heart (P0.001), the liver (P0.01), and in subcutaneous fat (P0.05). Oral and i.m. administration caused an increase in the concentration of alpha-tocopherol in the heart and liver (P0.001), subcutanous fat (P0.01), and tail fat (P0.05), on the 14th day after treatment. Oral administration improved retinol content of subcutanous fat on the 3rd day (P0.05). On the 14th day after i.m. administration, retinol content of tail fat and subcutanous fat (P0.01) had also improved. It can be concluded that i.m. administration increases tissue concentrations better than oral administration, and vitamin E administration improves the retinol content of adipose tissue, as well. Subcutaneous fat proved to be the first site of storage as compared to tail fat
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