Inhibition of angiotensin I converting enzyme and collagenase by water extracts of wild and cultivated herbs
1994
Kawakami, A. (Shinshu Univ., Minamiminowa, Nagano (Japan). Faculty of Agriculture) | Kayahara, H. | Inbe, T. | Tadasa, K.
Inhibition activity of angiotensin I converting enzyme (ACE) by water extracts from wild and cultivated herbs was examined in in vitro conditions to search the new material for making effective medicines to hypertension. Inhibition activity of bacterial collagenase (clostridium origin) by the extracts was also examined to check the specific inhibition of ACE activity, since the structural similarity of the active center of enzymes has been proposed between ACE and collagenase. Extracts from several plants such as rape (flower), mustard (leaf), udo (leaf), corn flower (flower), tarragon (leaf), dandelion (flower), Angelica pubescens (flower), Dystaenia ibukiensis (flower), italian parsley (leaf), arrowroot (leaf and flower), wisteria (blossom) and shallot (leaf) were revealed to possess the specific inhibitory potency to the ACE activity. These herbs are expected as the materials for making drugs for hypertension. In addition, extracts from some plants such as Lindera Praecox (nut), pomegranate (fruit), Agrimonia nipponica (flower), Geranium nepalense (leaf) and Smilax china (seed) were shown to inhibit collagenase activity specifically and they were expected to provide materials for some physiologically functional foods
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