Liposomes with alfa-tocopherol membrane
1996
Mojovic, Lj. (University of Belgrade, Belgrade (Yugoslavia). Faculty of Technology and Metallurgy) | Siler-Marinkovic, S. | Bugarski, D. | Jovcic, G. | Petakov, M. | Bugarski, B.
The preparation and biocompatibility of liposomes based on soya phospholipids encapsulated with alfa-tocopherol were studied. The binding efficiency of alfa-tocopherol was analysed by comparing two methods for liposome preparation. The degree of encapsulation achieved (88-93) suggested a high affinity of alfa-tocopherol for liposome membrane binding. The initial concentration of alfa-tocopherol had a significant effect on the degree of encapsulation, while the effect of method used was less pronounced. In general, a higher degree of encapsulation was achieved with smaller liposome size fractions. The in vivo application of the liposomes to CBA mice confirmed the biocompatibility and nontoxicity of such preparations. The analysis of hematological parameters in peripheral blood revealed that liposomes did not express cytotoxic effects on any of the parameters tested.
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