Investigation of polar petroleum fractions as potential antibiotics
1996
Dilber, S. (Farmaceutski fakultet, Beograd (Yugoslavia). Zavod za organsku hemiju) | Saban, M. (Hemijski fakultet, Beograd (Yugoslavia))
Most of the isolated fractions from petroleum samples (southeastern part of Pannonian basin, Yugoslavia) exhibited bactericidal action against Staphylococcus aureus only after standing at room temperature. Fractions of petroleum Ki-23, that exhibited most pronounced bactericidal action, were investigated in detail by IR-spectroscopy and C-CG-MS. It was found that the laboratory aging caused oxidation and isomerization, which were also responsible for antimicrobial activity. It was suggested that 4-methylfluoren and 3-methylphenantren have antimicrobial activity and they were considered as potential antibiotic.
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