Ocular irritation study of some pesticides in HET-CAM test
1997
Budai, P. | Varnagy, L. | Somlyay, I.M. | Varga, T. (Pannon Univ. of Agricultural Sciences, Keszthely (Hungary). Georgikon Faculty)
In recent years various in vitro methods have been developed to replace the heavily criticised Draize rabbit eye test for irritation testing. One of the most studied alternative methods is the Hens Egg Test Chorioallantoic membrane (HET-CAM). In our studies a comparative screening was done with a set of pesticides to establish parallel data on in vitro (BET-CAM) and in vivo (DRAIZE) results. The tested pesticide formulations were as follows: ARELON 500 FW (isoproturon), BANVEL 480 (dicamba), MEDALLON (glyphosate-trimesium), TELL 75 WG (primisulfuron). In most cases good correlation was found between the HET-CAM assessment and results from the Draize rabbit eye test. The actual form of the HET-CAM test is a valuable pre-screen for predicting ocular irritation potential of chemicals, and can be used to reduce the number of experimental animals. The HET-CAM test is useful as a part of a battery of tests to replace the Draize rabbit eye test.
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