Effect of chloridazon on sheep lymphocyte cultures in vitro in micronucleus assay
1998
Piesiva, E. (Univerzita Veterinarskeho Lekarstva, Kosice (Slovak Republic))
The herbicide chloridazon was tested for its ability to induce micronuclei in cytokinesis-block cells of cultured sheep peripheral blood lymphocytes at concentrations of 7 x 10E-6 M, 7 x 10E-5 M and 7 x 10E-4 M. A significant increase (P0.05) was achieved at the concentration of 7 x 10E-4 M in both donors. No significant differences in induction of micronucleus were found at either of the lower concentrations (7 x 10E-6 M and 7 x 10E-5 M). Results indicate that chloridazon acts as a cytotoxic compound by reducing the proportion of cytokinesis-block cells and has a weak effect on induction of the tested chromosomal changes (micronucleus)
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