The rate of sister-chromatid exchanges in cultured human peripheral blood lymphocytes treated with permethrin
1997
Djelic, N. (University of Belgrade, Belgrade (Yugoslavia). Faculty of Veterinary Medicine, Department of Biology) | Soldatovic, B. | Andjelkovic, M. | Milutinovic, R.
Permethrin is a broad spectrum non-cumulative synthetic pyrethriod insecticide, effective at low doses against a wide variety of ectoparasites of plants and animals. The frequency of sister chromatid exchanges (SCE) was examined on cultured human peripheral blood lymphocytes treated with high concentrations of permethrin. In order to ascertain possible cytotoxic or cytostatic effects, mitotic index was monitored for each experimental point. On the basis of the obtained results it can be concluded that permethrin did not increase SCE frequency significantly, wheareas mitotic activity was suppressed even at the lowest concentration tested.
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