Genotoxicity of pigments from seeds of Bixa orellana L. (Atsuete); 2: determined by lethal test
1997
Aranez, A.T. | Bayot, E. (Philippines Univ. Diliman, Diliman, Quezon City (Philippines). Inst. of Biology)
Pigments from dried atsuete (Bixa orellana L.) seeds were extracted by using chloroform AR grade. The chloroform was evaporated to dryness and the residue was designated crude atsuete chloroform extract (CE). CE was treated with petroleum ether AR grade. The residue was dried and designated as CE residue-petroleum ether extract (BE). BE was subjected to TLC. Male Namru strain (NMR) mice were given varying concentrations of BE and CE, and then mated with untreated females. More or less the same number of females mated with males given varying concentrations of BE became pregnant. However, more dead implants were observed in female mice mated with males given BE than those of the control indicating that BE is genotoxic. There were 2.1, 8.6, 18.3, and 20.4 percent dead implants in female mice mated with males given distilled water, DMSO, 200 mg BE per 1 kg body weight and 400 mg BE per 1 kg body weight, respectively. The percentage of female mice that became pregnant and had dead implants were 14.2, 33.0, 83.3, and 100 percent for female mice mated with males given distilled water, DMSO, 200 mg BE per 1 kg body weight, and 400 mg BE per 1 kg body weight, respectively. Pregnancy in female mice mated to males given DMSO, 200 mg CE per 1 kg body weight, and 400 mg CE per 1 kg body weight were 50, 75, and 25 percent, respectively. There were 5.7, 9.2, and 26.9 percent dead implants in female mice mated with males given DMSO, 200 mg CE per 1 kg body weight, and 400 mg CE per 1 kg body weight, respectively. CE like BE, is genotoxic
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