Histopathological changes in rabbit ileal loops caused by Aeromonas strains isolated from waters at Rawalpindi/Islamabad [Pakistan]
1998
Khalid, L. | Qazilbash, A.A. | Bari, A. (Quaid-i-Azam Univ., Islamabad (Pakistan). Dept. of Biological Sciences)
Presently three major types of Aeromonas infection can be recognized: systemic infections; wound infections and gastrointestinal infections, commonly expressed as watery or even choleric diarrhoea and dysenteric type of diarrhoea. Eleven Aeromonads were isolated from water, which included drinking and sewerage waters. All the eleven isolates (four Aeromonas hydrophila and Aeromonas sobria; three Aeromonas cavlae) were subjected to pathogenicity test using the rabbit ileal loop method. Eight of these isolates were confirmed to be pathogenic since they caused fluid accumulation in the ligated gut. Histological studies revealed that the pathogenic Aeromonads caused necrosis of villi, congestion in the mucosa, submucosa and lamina propria, in addition to haemorrhages in the lumen. Hence, it could be concluded that inoculation of live cells in ligated ileal loops can produce similar changes as have been reported by other workers who used toxins. Intact mucosa in most of the cases indicated that enterotoxin of Aeromonas evokes fluid secretion in the ileum by a process unrelated to change in mucosa. The present study shows that Aeromonas are a possible emerging diarrhoeal disease pathogen.
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