Resistance to emotional stress and cerebral ischemia in rats
1998
Koplik, E.V. (Russian Academy of Medicinal Sciences, Moscow (Russian Federation). P.K. Anokhin Institute of Normal Physiology) | Gannushkina, I.V. | Antelava, A.L. | Baranchikova, M.V. | Sosnovsky, A.S. | Sudakov, K.V.
The cortical cerebral blood flow was examined by laser-doppler flowmeter (Peri Flux PF-3, Sweden) in rats with different sum of resistance to emotional stress (determined by stress trials in open field). The emotional stress (immobilization with simultaneous electro-skin stimulation) was caused three days after the stress was examined by following the surviving, changes of the thymus and suprarenal gland weight. The rats, which showed longer latent period of the first movement and passing through the central square, lower locomotion and exploratory activity had small surviving number and greater hypertrophy of adrenal gland caused by stress. Also, in these rats cerebral blood flow was greater and they were more sensible to the cerebral ischemia, caused by bilateral carotid occlusion. The presented results showed that behaviour trials can provide the basis for the prediction of the rats resistance to the emotional stress and cerebral ischemia.
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