Some metabolic alterations induced by high doses of unilocular filtered hydatid cyst fluid on rabbit liver
1997
Tanveer, A. | Saeed, S. | Anwar, Z. (Punjab Univ., Lahore (Pakistan). Dept. of Zoology)
Out of 46 rabbits acclimatized for 2, weeks to the optimal conditions of animal house, 23 were inoculated upto 7 weeks with different doses (0.50, 0.75, 1.0, 1.25, 1.50, 1.50, 1.50 ml) of filtered hydatid cyst fluid (FHCF) of sheep origin. Each dose was daily inoculated for one week and then calculated according to their body weight. Control rabbits were given distilled water with similar protocol. Three treated and three control rabbits were weekly slaughtered and biochemical analysis of liver tissue were made. It was noted that body weight increased gradually, in both control and experimental rabbits but when both groups were compared, a significant reduction was noted for all the rabbits treated with FHCF except the last three doses which were kept constant. Their respective specific growth rate also showed increasing trend but with lot of fluctuations. In the liver tissues of treated rabbits increase in total protein, soluble protein (P0.001), glutamate oxaloacetate transaminase (P0.001), glutamate pyruvate transaminase (P0.01), bilirubin (P0.05), alkaline phosphatase (P0.001), acid phosphatase, ribonucleic acid, deoxyribonucleic acid and free amino acid was found statistically significant when compared with their respective controls, while cholesterol level decreased in all the treated rabbits.
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