The influence of administering of preparation carbimazol on the morphology and function of ram testes
1999
Cigankova, V. (University of Veterinary Medicine, Kosice (Slovak Republic)) | Bekeova, E.
Investigations were carried out to observe the influence of long-term peroral administration of thyreostatic preparation 1-carbaetoxy-3-methyl-2-thioimidazoline on the level of triiodothyronine(T3), thyroxine (T4), in blood serum, the morphological ficture of the testes; and the quality of ram seminal fluid. The concentration of T(3) varied reaching values close to the lower physiological limit and the concentration of T4 decreased to the hypothyroid level. The morphological picture of testes of sexually mature hypothyroid rams, observed by means of light microscopy and transmission electron microscopy, points to the disturbances in the course of spermatogenesis. The cytoplasms of Certoli cells showed accumulation of lipid droplets. The degeneration of some germ cells could be observed and the lumen of seminiferous tubules contained peeled-off immature cells of seminiferous epithelium. No marked changes were observed in the volume or density of seminal fluid while the motility of sperms was slightly reduced. Marked increase in the occurrence of abnormal sperms was detected in experimental rams in comparison with control
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