Effects of vitamine E and selenium on some metabolic and immunological parameters in carbon tetrachloride treated sheep
2000
Milad, K. | Kovac, G. | Bajova, V. | Mojzisova, J. (University of Veterinary Medicine, Kosice (Slovak Republic))
In six non-pregnant Merino sheep the effect of a single dose of vitamin E and selenium on some immunological parameters such as blastogenic responses of lymphocytes and phagocytic functions of leukocyte (phagocytic index and metabolic activity index) response to carbon tetrachloride (CCl4) intoxication were investigated. The sheep with an average age of 3 years were divided randomly into two groups: the first group was injected subcutaneously a single dose of 400 mg tocopherol acetate and 12 mg selenium as sodium selenite and the second group served as control. After 24 hours the sheep of both groups were dosed orally with 0.05 ml/kg live body weight carbon tetrachloride via a stomach tube to the rumen.Blood samples were collected one day before and on the second, third, fourth, tenth and sixteenth day after vitamin E and selenium administration, and were examined for vitamin E and selenium concentrations and total serum activities of lactate dehydrogenase (LDH) and gamma-glutamyl transferase (GGT).The serum vitamin E and selenium concentrations were significantly (P 0.001) higher in the experimental group than in the control group. Similarly, the administration of vitamin E and selenium produced significant differences (P 0.01) in activity of GGT. An evaluation of immunological parameters before anz administration and seven days after vitamin E and selenium administration showed no statistical differences except the metabolic activity index in the control group which decreased significantly (P 0.05) after the administration.In conclusion, neither vitamin E + selenium nor CCl4 administration effects on the measured immunological parameters were determined in the present study
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