Disposition of antimicrobial drugs in tiger giant prawn
1994
Limpoka, M. | Chaianan, P. | Pongskorn, S. (Kasetsart Univ., Bangkok (Thailand). Faculty of Veterinary Medicine)
Pharmacokinetic data and information on absorption, tissue clearance, tissue distribution and excretion of nine proposed antimicrobial drugs were investigated in giant prawn (Penaeus monodon Fabricus). Two or more dosage levels of each drug were administered intramuscularly and orally to each experimental prawn and mixed through two different types of diet, pelleted-diet and fish-flesh diet and fed to the prawn for 5 consecutive days. The total of 102 field experiments were accomplished. The effect of dose size, route of administration, type of feed and feed component, therapeutic concentrations and residual concentrations of each drug in the edible part of prawn tissue would be assessed from these studies. Differences in pharmacokinetic behaviors following different routes of administration and dosage levels were observed. A magnitude of possible factors such as pH and concentrations of drug solution, drug formulation, and volume of drug administered to each individual prawn, and in addition, different types of feed, feed components and feed formulations needed to be examined for further elucidate the differences. There are a considerable number of complicating factors which make the study of drug kinetics in aquatic animals more difficult than in land animals. No single kinetic study is subject to all the questions needed to be solved in using drugs in aquatic species.
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