Effect of lead on tissue deposition in rats
1991
Vipaporn Na-Thalang | Pongsri Jittanoonta | Wanpen Mesomya (Kasetsart Univ., Bangkok (Thailand). Inst. of Food Research and Product Development)
Toxicity of lead towards tissue deposition in rats was evaluated by short-term feeding studies at dietary levels of 0, 50, 100 and 500 ppm of lead acetate for 3 and 6 months. There were no significant differences in food intake. However, there were slight differences in the body weight gained. The relative organ weight and relative organ to brain weight ratios of liver in the 6 months studies showed statistically significant differences (p0.05) and showed a tendency to decrease with increasing lead content. Studies on the deposition of lead in the internal organs of rats revealed the bones, kidneys and liver accumulated the highest lead concentration. In addition, concentration of lead in liver and kidney were significantly correlated (p0.05). Furthermore, faeces was found to be the predominant route of lead excretion during the first 24 hrs.
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