Changes in the tracheal epithelium during 24 hours after inhalation of mineral water
2001
Konradova, V. | Vajner, L. | Uhlik, J. (Karlova Univ., Prague (Czech Republic). Ustav Histologie a Embryologie) | Zocova, J.
Inhalation of aerosol of mineral water is frequently used in therapy of various respiratory disorders. Ultrastructure of the airway epithelium in rabbits and character of glycoconjugates produced by secretory cells were studied immediately and 24 h after 10-min inhalation of this aerosol. Goblet cells were overstimulated and the mechanism of mucus evacuation was accelerated. The exhausted goblet cells mostly took part in further secretory cycles, but the number of degenerated secretory elements gradually increased in the course of 24 h. Cells not entirely filled with secretory granules prevailed in the epithelium. Compared with controls, significant decrease in the acid sulphated glycoconjugates in the secretion of the goblet cells was accompanied by an increase of the acid sialylated ones immediately after inhalation. Twenty-four hours post-exposure, significant decrease in total sialylated glycoconjugates was ascertained. Significant decrease in number of kinocilia/square microm was accompanied by an increase in percentage of altered cilia. Morphological signs of impaired self-cleaning ability of the airway epithelium were encountered during the whole experiment.
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