Quantitative trait loci (QTLs) mapping for growth traits in the mouse: a review | [Detection et localisation des genes (QTL, quantitative trait loci) influencant la croissance de la souris]
2001
Corva, P.M. (University of California, Davis (Etats Unis). Department of Animal Science) | Medrano, J.F.
The attainment of a specific mature body size is one of the most fundamental differences among species of mammals. Moreover, body size seems to be the central factor underlying differences in traits such as growth rate, energy metabolism and body composition. An important proportion of this variability is of genetic origin. The goal of the genetic analysis of animal growth is to understand its "genetic architecture", that is the number and position of loci affecting the trait, the magnitude of their effects, allele frequencies and types of gene action. In this review, the different strategies developed to identify and characterize genes involved in the regulation of growth in the mouse are described, with emphasis on the methods developed to map loci contributing to the regulation of quantitative traits (QTLs)
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