Molecular biology of porcine adenoviruses
1999
Tuboly,T.
Although porcine adenoviruses (PAdV) are present in swine populations worldwide, they usually do not cause any disease, or if they do, it only manifests (with the exception of PAdV-4) as a mild diarrhea or mild respiratory signs.The importance of adenoviruses is constantly growing as there is a possibility of developing them into viral vector vaccines against more significant swine pathogens.The author summarizes the brief history of porcine adenoviruses, focusing on the present state of the art.He describes the latest developments in the exploration of the genome of all currently recognized PAdV serotypes.There are several possibilities for the insertion of foreign genes into the adenovirus genome.The author also mentions some examples, such as transmissible gastroenteritis or classical swine fever, where porcine adenovirus-based recombinant vaccines would be useful.He also describes some of the risks of using live recombinant viruses and the necessity of virological surveys before even starting to design such vaccines.
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