Disposition kinetics and dosage regimen of ceftriaxone in crossbred calves
1999
Srivastava,A.K. | Johal,B.
In 10 healthy crossbred calves, 1-1.5 years of age and weighing 60-175 kg, injected i.v. with ceftriaxone at 10 mg/kg, the peak plasma concentration of ceftriaxone at 1 min was 84.0+-1.55 cg/ml which declined to 0.43+-0.05 cg/ml at 8 h.The values of elimination half-life (t1/2beta), volume of distribution Vd (area) and total body clearance (CIB) were 4.39+-0.63 h, 1.9+-0.19 litres/kg and 0.31+-0.01 litres/kg per h, respectively.Approximately 41% of total administered drug was recovered in the urine within 24 h of its administration.The plasma protein binding of ceftriaxone was concentration-dependent with an overall mean of 38.55%.The binding capacity of ceftriaxone to plasma proteins and the dissociation rate constant of protein-drug complex were 20.1 X 10-8+-18.4 X 10-8 mole/g and 1.07 X 10-6+-0.52 X 10-6 mole, respectively.It was calculated that an appropriate intravenous dosage regimen of ceftriaxone in cattle is 12 mg/kg repeated at 24 h.
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