Inhibition of glucan synthesis by casein polymers crosslinked by glutaraldehyde
1998
Hayashida, O. (Tokyo Univ. of Agriculture and Technology, Fuchu (Japan). Faculty of Agriculture) | Mori, F. | Hasumi, K. | Endo, A.
Glutaraldehyde-crosslinked alpha-casein polymers with molecular masses of 1 - 5 x 10(5) were found to inhibit adhesive insoluble glucan formation catalyzed by glucan synthases from Streptococcus sobrinus B13, a cariogenic oral bacterium. Of the three subcomponents of the glucan synthases tested, primer-dependent insoluble glucan synthase was inhibited specifically by the Mr - 2.7 x 10(5) polymer at a concentration of 1.4-8.5 mu-g/ml. The polymer was also active in inhabiting the artificial pl
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