Changes in nitrogen balance and glucose metabolism in rats fed a high-phosphorus diet
1998
Ohdachi, J. (Tokyo Univ. of Agriculture (Japan)) | Tanaka, M. | Masuyama, R. | Uehara, M. | Suzuki, K. | Kanke, Y. | Goto, S.
Changes in growth, nitrogen balance and glucose metabolism were investigated in rats given a high-phosphorus (P) diet for 3 weeks. Eighteen rats were divided into 3 groups: the first group (NF) was fed a normal P diet (0.5% P) freely, the second group (HF) was fed a high-P diet (1.5% P) freely, and the third group (NR) was fed a normal P diet, being restricted to the same amount of food consumed by the rats given the high-P diet. Nitrogen retention was decreased in the rats fed the high-P diet compared with the rats fed the normal P diet. Excretion of urinary 3-methylhistidine in the rats fed the high-P diet was higher than that in the rats pair-fed the normal P diet. The concentration of serum glucose in the rats fed the high-P diet was higher than that in the rats pair-fed the normal P diet. Content of liver glycogen in the rats fed the high-P diet were detected. The activity of liver glucose-6-phosphatase [EC 3.1.3.9] was decreased in the rats fed the high-P diet compared with those fed the normal P diet. These results indicate that rats fed a high-P diet utilize not only glucose and fatty acid but also protein as an energy source
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