Lactate dehydrogenase pattern in tissues of pigs exposed to arsenic and cadmium - a pilot study
2001
Salplachta, J. | Vinkler, A. (Veterinarni a Farmaceuticka Univ., Brno (Czech Republic))
The aim of this study was to compare the sensitivity of various tissues of young pigs (Large White) chronically exposed to low doses of cadmium (Cd or CdSO4, 10 mg Cd/kg body weight per day in food within the interval of 35 to 239 days after birth, then 20 mg Cd/kg body weight untill day 443) or arsenic (10 mg As2O3/kg body weight in food within interval 35 to 186 days followed by 20 mg As2O3/kg body weight within 64 days). The data of experimental and control tissues (myocardial atrium, diaphragm, kidney, liver, lung, spleen, skeletal muscle) were evaluated using the sum of vectors method (SV). Cadmium experiment: significant differences (P 0.05) were found in lung, diaphragm, spleen, and liver. The relative order of differences between experimental and control tissues (lung diaphragm spleen liver) indicates different sensitivity of these tissues to damage. Arsenic experiment: significantly different LD pattern (P 0.05) was only found in liver. Our data indicate that pig tissues differ in sensitivity to chronic low-level Cd or As load. The liver was found to be the most sensitive among pig tissues to both elements. A study of tissue LD pattern may be complementary to functional tests of organs.
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