Do works concerning ferrochromium alloys mean risk for the inhabitants living in their surrounding? A cytogenetic study
2001
Halasova, E. | Bukovska, E. | Kukura, F. (Comenius Univ., Martin (Slovak Republic). Jessenius Medical Faculty) | Cervenova, T. | Oravec, P. | Kereskeni, J.
In the present study cytogenetic markers as chromosomal aberrations, sister chromatid exchanges and micronuclei were evaluated in peripheral lymphocytes of 26 foundry metallurgists exposed to increased level of chromium, 26 inhabitants living in the surroundings of the works within a distance of 5 km, and 26 inhabitants living in uncontaminated area in a distance more than 30 km from the works. Our goal was to verify whether side-products arising during the production of ferrochromium alloys and released into the air in the surroundings of the works do have a cytogenetic effect on the there living population. All of the cytogenetic markers were significantly increased (P 0.001) only in the group of the workers, in comparison with the other two groups. We did not find increased levels of the observed cytogenetic markers in peripheral lymphocytes neither of inhabitants living in an uncontaminated area nor of inhabitants living the neighbourhood of the works. Smoking proved to be a significant positive predictor for SCE frequency in all investigated groups. There was no significant difference in frequency of chromosomal aberrations and micronuclei between smokers and non-smokers. We can conclude that only occupational exposure to chromium increases the frequency of chromosomal aberrations, sister chromatid exchanges, and micronuclei in peripheral lymphocytes
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