The effects of endothelin receptor blockade on the course of experimental postischaemic acute renal failure
2002
Miloradovic, Z. (Institute for Medical Research, Belgrade (Yugoslavia)) | Jerkic, M. | Jovovic, Dj. | Mihailovic-Stanojevic, N. | Stosic, G. | Markovic-Lipkovski, J.
The main goal of this study was to examine the efficacy of endothelin (ET) receptor blockade in the course of experimental postischaemic acute renal failure (ARF). Experiments were performed on male adult Wistar rats. The right kidney was removed before renal ischaemia (by clamping the left renal artery for 45 minutes). The experimental groups received either bosentan (ETA/ETB - receptor antagonist; 10 mg/kg/b.m.) or vehicle (saline) in the femoral vein 20 minutes before, during and 20 minutes after ischaemia. All parameters were measured 24 hours after reperfusion. The obtained results clearly demostrate that bosentan yields beneficial effect on ARF. Bosentan improves both renal haemodynamic and functional parameters after AFR, while lesions of tubular epithelial cells, the principal targets of injury in ARF, are less serious in bosentan-treated rats than in the control ARF rats. This strongly suggests that endothelins have an improtant role in the development of ischaemia/reperfusion injury and contributes to the promotion of bosentan in future clinical practice.
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