Milk components with anticancer potential
2002
Parodi, P.W. (Human Nutrition Program, Queensland (Australia). Dairy Research and Development Corporation)
Milk contains a number of components with anticancer potential. The fat phase contains conjugated linoleic acid (CLA), which is a potent inhibitor of mammary tumorigenesis. Sphingomyelin and other sphingolipids protected against colon tumour development in mice. Butyric acid can inhibit mammary tumour occurrence in rats, while 13-methyltetradecanoic acid suppressed cell growth in a number of human cancer cell lines and inhibited the growth of human prostate and liver cancer cells implanted in mice. Milk lipids also contain the common anticancer agents beta-carotene and vitamin A. Milk protein, particularly whey protein, has potent antitumour action in animal models of colon and mammary tumorigenesis and is superior to other proteins such as beef and soy. Lactoferrin inhibited tumour development in rodent colon, lung, oesophagus, bladder and tongue. Lactoferrin can also inhibit angiogenesis and prevent metastases. Milk is a rich source of calcium. A large number of animal studies and human epidemiological and intervention studies suggest calcium can help prevent colon adenoma and carcinoma.
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