Blood flow evaluation in SA-1 tumours in mice using macromolecular contrast agents in magnetic resonance imaging
2001
Ivanusa, T. (Ljubljana Univ. (Slovenia). Veterinary Fac.)
Magnetic resonance imaging (MRI) is a diagnostic tool for soft tissue differentiation. This can be improved by the use of contrast media: low-molecular-weight media such as clinically approved Gd-DTPA (gadolinium(III)-diethilentriaminepentaacetic acid) and macromolecular contrast media. Macromolecular contrast agents are being developed to investigate blood pool, to specifically enhance the blood pool and to evaluate capillary-integrity. These agents are not available yet for clinical use. Two prototype macromolecular contrast media were used in this study: gadomer-17 and polylysine-Gd-DTPA and compared to Gd-DTPA. With their use the quality of tumor vessels was described, specifically blood volume (BV) and permeability (PS) of untreated tumors and tumors treated with vinblastine or electric pulses. The study has shown that both macromolecular contrast media are superior to Gd-DTPA in determining tumor vessels, i.e. BV and PS. With the use of dynamic contrast-enhanced MRI the efficacy of both treatment was shown as a decrease in BV and PS values. Application of electric pulses was more effective than vinblastine. Amongst the three used contrast media, gadomer-17 is the most appropriate for the future clinical use. The results of the present research are new accomplishment in the use of macromolecular contrast media for evaluation of tumor blood pool and understanding of vinblastine or electric pulses action on tumor vessels.
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