The determination of the immunotoxic and genotoxic potential of fungicide dichlofluanid on sheep leukocytes in vitro
2002
Kovalkovicova, N. | Pistl, J. | Sutiakova, I. | Mikula, I. | Novotny, J. | Holovska, V. | Legath, J. (University of Veterinary Medicine, Kosice (Slovak Republic))
Dichloflaunid is one of the most widely used fungicides and wood preservatives. Its immunotoxic effect was evaluated in vitro on sheep peripheral blood phagocytes by the iodo-nitro-tetrazolium reductase test (INT) at concentrations of 1E-1-10E-8 mol/l. The significant inhibitory effect of fungicide on the metabolic activity (MA) of phagocytes was registered at concentrations of 10E-1 (p 0.001 - 10E-3 mol/l1 (p 0.05). The genotoxic potential of dichlofluanid was examined by micronucleus assay in sheep lymphocytes at concentrations of 10E-4 - 10E-6 mol/l. The significant increase in the micronucleus frequency was not observed at the concentrations tested
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