The effect of nutritional status on the magnitude of acute phase protein response in female rats
2003
Grigorov, I. | Milosavljevic, T. | Bogojevic, D. | Ivanovic-Matic, S. | Petrovic, M. | Uskokovic, A. (Institute of Biological Research "Sinisa Stankovic", Belgrade (Serbia and Montenegro). Department for Molecular Biology)
In response to imflammation, infection and tissue injury, the sequence of events known as acute-phase (AP) response is induced and a number of plasma proteins, called acute-phase proteins (APPs) are synthesized in the liver, as a part of the host defence mechanism. Any condition which impairs acute phase protein response (APPR) and hence organism's ability to restore homeostasis may limit its survival in various stress circumstances. Malnutrition is well-known causes of several metabolic, immune and neuroendocrine dysfunctions and this study was aimed at investigating its effect on the magnitude of normal APPR and in relation to turpentine injury. Malnutrition in female Wister rats was induced by food restriction during six weeks period until they riched and kept body weight to 50% of that of ad libitum fed mates. Results of the rocket immunoelectrophoresis revealed that malnutrition alone or in conjugation with turpentine was capable of elevating an expression of one of APPs, haptoglobin (Hp). Based on the studies of liver-specific regulatory proteins that bind to hormone regulatory elements of Hp gene and thus determine its expression we found that malnutrition probably modulated Hp response by changing the expression of active members of C/EBP, STAT and NF-kB transcription factor families.
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