Dimethyl sulfoxide induces acute phase response in rat
2003
Ivanovic-Matic, S. | Dinic, S. | Mihailovic, M. | Poznanovic, G. | Grigorov, I. | Bogojevic, D. (Institute of Biological Research "Sinisa Stankovic", Belgrade (Serbia and Montenegro). Molecular Biology Laboratory)
We have studied the ability of dimethyl sulfoxide (DMSO) to induce the acute-phase response (APR) in rats. The injection of DMSO to laboratory rats caused a rapid increase of the plasma corticosterone concentration. It peaked 2 h after DMSO application and was 300% higher relative to the control. By 12 h, the corticosterone concentration returned to the basal value. The elevated corticosterone concentration induced an increase of acute phase proteins (APP) in sera 24 h after DMSO administration. At 24 h after DMSO administration the relative serum concentration of cysteine proteinase inhibitor (CPI) increased about 710%, alfa1-acid glycoprotein (AGP) 630%, alfa2-macroglobulin (MG) 510%, gama fibrinogen (Fb) 420%, haptoglobin (Hp) 280%, whereas the relative concentration of albumin, a "negative" APP, decreased to 93% in relation to the corresponding control values. Such changes of APP and corticosterone concentrations after DMSO treatment are comparable to those observed during the APR induced by other irritants. On the basis of these findings we concluded that administration of DMSO induces the APR in rats. Therefore, we suggest a more cautious use of DMSO in clinical purposes.
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