A new type of cysteine proteinase inhibitor, the salarin gene from Atlantic salmon (Salmo salar L.) and Arctic char (Salvelinus alpinus)
2003
Olonen, A. ((University of Helsinki (Finlande). Institute of Biotechnology, Protein Chemistry Laboratory)) | Kalkkinen, N. | Paulin, L.
Salarin is a 43 kDa glycoprotein which is found so far only in salmonid fish species. It is a strong inhibitor of cysteine proteinases. Here we characterised the salarin gene from Atlantic salmon and cDNA from Arctic charr. The salarin gene has 13 exons and 1026 by long coding sequence. The translated amino acid sequence has four similar domains. The sequence resembles the proregion of cathepsins, known to inhibit cysteine proteinases. Salarin can be a new type of cysteine proteinase inhibitor
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