Recent data on the development of cloned embryos derived from reconstructed eggs with adult cells | Données récentes sur le développement des embryons par clonage somatique avec des cellules adultes
2003
Thibault, C. ((Institut National de la Recherche Agronomique, Jouy en Josas (France). Centre de Jouy en Josas, UMR Biologie du Développement et Reproduction))
Production of cloned embryos by nuclear transfer from adult somatic cells is a novel and promising technique in animal biotechnology. In spite of numerous reported viable offspring in various species, the efficiency of the technique remains very low. Embryonic and fetal mortality occurs all along pregnancy and during the perinatal life, even months after birth. Both embryonic and placental dysfunctions might be involved. However the precise causes of such developmental failures are still unknown. In the present review, we report data from different studies which described the main defaults which have been observed after embryonic cloning in various species. The putative molecular and cellular causes of these developmental failures are discussed
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