Effect of a single sublethal dose of permethrin on the development of liver in chick embryo
2004
Anwar, K.K. (University of Azad Jammu and Kashmir, Muzaffarabad (Pakistan). Dept. of Zoology) | Ali, S.S. | Shakoori, A.R.
Present study was designed to evaluate the toxicity of single sublethal doses of various concentrations (25, 50, 100 and 200 ppm) of permethrin insecticide on the liver of 16-day old chick embryo. Permethrin was injected in to the eggs on day `0' of incubation. Liver was analyzed for the estimation of a few enzyme activities and some biochemical constituents. Among enzymes, the activities of alkaline phosphatase (AkP), acid phosphatase (AcP), aspartate aminotransferase (AST), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) were significantly decreased, whereas the activity of amylase remained unchanged. From among biochemical components glucose, glycogen, total protein, soluble protein, urea and RNA contents were significantly decreased, while total lipids and FAA content were significantly elevated. However, cholesterol, uric acid and DNA contents remained unaltered with permethrin treatment. Permethrin- induced histopathological changes in liver showed increased sinusoidal spaces in hepatic parenchyma, cytoplasmic vacuolations in hepatocytes, hepatocytic nuclear condensation, fatty degeneration, hydropic degeneration and necrosis of hepatocytes. In addition, a few histological parameters like number of cells/microscopic field, number of nuclei/cell and the number of nucleoli/nucleus were also affected with permethrin treatment. The insecticide therefore had a serious toxic effects on the developing liver.
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