Immunization of rabbits against Boophilus microplus using midgut and salivary glands
2002
Asif, M.
The current research was conducted as a simulation model in rabbits for the development of vaccines against cattle ticks Boophilus microlus using tick salivary glands & midgut as the sources, of antigens. The comparative efficacy of these vaccines was evaluated on the basis of antibody titres and tick rejection on the host in terms of mortality, decrease in egg laying and decrease in hatchability of eggs. It was found that the vaccine prepared from the midgut of B. microplus gave better results than the vaccine prepared from salivary glands. The highest percentage of dead ticks was observed in animals which were given midgut vaccine (21.8251). This vaccine, also caused a significant decrease in the egg laying capacity of the ticks (35.83%). However, none of the vaccines had any significant effect on the hatchability of eggs laid by the ticks. The highest antibody titers were observed in rabbits injected with midgut vaccine (GMT = 5.50), which was 45.28% higher than rabbits given salivary gland vaccine. The overall success rate for midgut vaccine, in terms of tick mortality on host, decrease in egg laying capacity and antibody titer, was, 37.06% for midgut vaccine while only 16.51% for salivary gland vaccine.
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