Histological and histochemical alterations induced in the testicular tissue of mice intoxicated with benomyl
2004
Sakr, S.A. | Okdah, Y.A. (Menoufia Univ., Shebin El-Kom (Egypt). Dept. of Zoology)
Benomyl is a fungicide of benzimidazoles group used against a wide range of fungal diseases of crops and vegetables. The effect of benomyl on the testicular tissue of mice was investigated. Treating mice with benomyl at a dose level of 1/10LD50 3 times/week for 3 weeks significantly reduced the diameter of the somniferous tubules and the height of the germinal epithelium. Moreover, the treatment induced many histopathological changes including degeneration of the spermatogenic cells, absence of sperm bundles and congestion of blood vessels. Histochemical results revealed reduction in total carbohydrates and total proteins in the spermatogenic cells. These alterations were time-dependent and were obvious in mice treated with benomyl for 3 weeks. It is speculated that one or more metabolite of benomyl may have endocrine disrupting effects resulting in the inhibition of spermatogenesis.
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