Synthesis of antiinflammatory steroids intermediates from steroids extracted from industrial waste of agave sisalana
1997
Ngampong Kongkathip | Boonsong Kongkathip | Naratitt Noimai | Suvipa San-oon (Kasetsart Univ., Bangkok (Thailand). Faculty of Science. Dept. of Chemistry)
Sisal fibers from Agave sisalana's leaves are used in fiber industrial factories and handicraft manufacture. The waste juice from the sisal industrial process contains mainly two steroids, Hecogenin and Tigogenin, which are used as starting material for steroid drugs synthesis. The crude steriods were obtained by fermentation, acid hydrolysis and then solvent extraction of the waste juice. Purification of the crude steroids was achieved by quick column chromatography followed by column chromatography. A simple one-pot reaction of Hecogenin gave 3 beta-acetoxy-5a-pregn-16-ene-12, 20-dione and then epoxidation of the obtained compound yielded 16 alpha, 17 alpha-epoxy-3b-hydroxy-5alpha-pregnane-12, 20-dione which is and intermediate for synthesis of Betamethasone, Dexamethasone and Triamcinolone, anti-inflammatory drugs.
Afficher plus [+] Moins [-]Mots clés AGROVOC
Informations bibliographiques
Cette notice bibliographique a été fournie par Kasetsart University
Découvrez la collection de ce fournisseur de données dans AGRIS